Tenecteplase versus alteplase before endovascular thrombectomy (EXTEND-IA TNK): A multicenter, randomized, controlled study

BCV Campbell; PJ Mitchell; L Churilov; N Yassi; TJ Kleinig; B Yan; RJ Dowling; SJ Bush; HM Dewey; V Thijs; M Simpson; M Brooks; H Asadi; TY Wu; DG Shah; T Wijeratne; T Ang; F Miteff; C Levi; M Krause; TJ Harrington; KC Faulder; BS Steinfort; P Bailey; H Rice; L de Villiers; R Scroop; W Collecutt; AA Wong; A Coulthard; PA Barber; B McGuinness; D Field; H Ma; W Chong; RV Chandra; CF Bladin; H Brown; K Redmond; D Leggett; G Cloud; A Madan; N Mahant; B O’Brien; J Worthington; G Parker; PM Desmond; MW Parsons; GA Donnan; SM Davis

Journal article

Tenecteplase versus alteplase before endovascular thrombectomy (EXTEND-IA TNK): A multicenter, randomized, controlled study

BCV Campbell, PJ Mitchell, L Churilov, N Yassi, TJ Kleinig, B Yan, RJ Dowling, SJ Bush, HM Dewey, V Thijs, M Simpson, M Brooks, H Asadi, TY Wu, DG Shah, T Wijeratne, T Ang, F Miteff, C Levi, M Krause Show all

International Journal of Stroke | SAGE PUBLICATIONS LTD | Published : 2018

DOI: 10.1177/1747493017733935

Abstract

Background and hypothesis: Intravenous thrombolysis with alteplase remains standard care prior to thrombectomy for eligible patients within 4.5 h of ischemic stroke onset. However, alteplase only succeeds in reperfusing large vessel arterial occlusion prior to thrombectomy in a minority of patients. We hypothesized that tenecteplase is non-inferior to alteplase in achieving reperfusion at initial angiogram, when administered within 4.5 h of ischemic stroke onset, in patients planned to undergo endovascular therapy. Study design: EXTEND-IA TNK is an investigator-initiated, phase II, multicenter, prospective, randomized, open-label, blinded-endpoint non-inferiority study. Eligibility requires ..

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University of Melbourne Researchers

Bruce Campbell Author

Peter Mitchell Author

Leonid Churilov Author

Nawaf Yassi Author

Grants

Awarded by Stroke Foundation

Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Campbell reports research support from the National Health and Medical Research Council of Australia (GNT1043242, GNT1035688 GNT1113352, GNT1111972), Royal Australasian College of Physicians, Royal Melbourne Hospital Foundation, National Heart Foundation, Stroke Foundation of Australia.