Genetic Diversity of Infectious Laryngotracheitis Virus during In Vivo Coinfection Parallels Viral Replication and Arises from Recombination Hot Spots within the Genome
Carlos A Loncoman, Carol A Hartley, Mauricio JC Coppo, Paola K Vaz, Andres Diaz-Mendez, Glenn F Browning, Maricarmen Garcia, Stephen Spatz, Joanne M Devlin
APPLIED AND ENVIRONMENTAL MICROBIOLOGY | AMER SOC MICROBIOLOGY | Published : 2017
Recombination is a feature of many alphaherpesviruses that infect people and animals. Infectious laryngotracheitis virus (ILTV; Gallid alphaherpesvirus 1) causes respiratory disease in chickens, resulting in significant production losses in poultry industries worldwide. Natural (field) ILTV recombination is widespread, particularly recombination between attenuated ILTV vaccine strains to create virulent viruses. These virulent recombinants have had a major impact on animal health. Recently, the development of a single nucleotide polymorphism (SNP) genotyping assay for ILTV has helped to understand ILTV recombination in laboratory settings. In this study, we applied this SNP genotyping assay ..View full abstract
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Awarded by Australian Research Council
This work was supported by the Australian Research Council (FT140101287). Carlos A. Loncoman is supported by Becas Chile, CONICYT, Gobierno de Chile.