The role of whole-brain diffusion MRI as a tool for studying human in vivo cortical segregation based on a measure of neurite density
Fernando Calamante, Ben Jeurissen, Robert E Smith, Jacques-Donald Tournier, Alan Connelly
MAGNETIC RESONANCE IN MEDICINE | WILEY | Published : 2018
PURPOSE: To investigate whether diffusion MRI can be used to study cortical segregation based on a contrast related to neurite density, thus providing a complementary tool to myelin-based MRI techniques used for myeloarchitecture. METHODS: Several myelin-sensitive MRI methods (e.g., based on T1 , T2 , and T2*) have been proposed to parcellate cortical areas based on their myeloarchitecture. Recent improvements in hardware, acquisition, and analysis methods have opened the possibility of achieving a more robust characterization of cortical microstructure using diffusion MRI. High-quality diffusion MRI data from the Human Connectome Project was combined with recent advances in fiber orientatio..View full abstract
Awarded by Research Foundation Flanders
Grant sponsor: National Health and Medical Research Council of Australia; Grant sponsor: Australian Research Council; Grant sponsor: Victorian Government's Operational Infrastructure Support Grant. Grant sponsor: Research Foundation Flanders; Grant number: 12M3116N (to B.J.). Data were provided in part by the Human Connectome Project, WU-Minn Consortium, funded by the 16 National Institutes of Health (NIH) Institutes and Centers that support the NIH Blueprint for Neuroscience Research and by the McDonnell Center for Systems Neuroscience at Washington University.