Journal article

Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study.

Gilbert Bensimon, Albert Ludolph, Yves Agid, Marie Vidailhet, Christine Payan, P Nigel Leigh, undefined NNIPPS Study Group

Brain | Published : 2009


Parkinson plus diseases, comprising mainly progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are rare neurodegenerative conditions. We designed a double-blind randomized placebo-controlled trial of riluzole as a potential disease-modifying agent in Parkinson plus disorders (NNIPPS: Neuroprotection and Natural History in Parkinson Plus Syndromes). We analysed the accuracy of our clinical diagnostic criteria, and studied prognostic factors for survival. Patients with an akinetic-rigid syndrome diagnosed as having PSP or MSA according to modified consensus diagnostic criteria were considered for inclusion. The psychometric validity (convergent and predictive) of the NNIPPS ..

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