Journal article
Effects of estrogens on adipokines and glucose homeostasis in female aromatase knockout mice
ML Van Sinderen, GR Steinberg, SB Jørgensen, J Honeyman, JD Chow, KA Herridge, AL Winship, E Dimitriadis, MEE Jones, ER Simpson, WC Boon
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2015
Abstract
The maintenance of glucose homeostasis within the body is crucial for constant and precise performance of energy balance and is sustained by a number of peripheral organs. Estrogens are known to play a role in the maintenance of glucose homeostasis. Aromatase knockout (ArKO) mice are estrogen-deficient and display symptoms of dysregulated glucose metabolism. We aim to investigate the effects of estrogen ablation and exogenous estrogen administration on glucose homeostasis regulation. Six month-old female wildtype, ArKO, and 17β-estradiol (E2) treated ArKO mice were subjected to whole body tolerance tests, serum examination of estrogen, glucose and insulin, ex-vivo muscle glucose uptake, and ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This research was supported by Australian National Health and Medical Research Council project grants ID 338510, and 628553 and program grant 441100. MLS was supported by Monash Postgraduate Scholarship; WCB was supported by a Fred P. Archer Fellowship. The authors acknowledge the support of the Victorian Government through the Operational Infrastructure Scheme. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.