Journal article

Psychological distress and ischaemic heart disease: cause or consequence? Evidence from a large prospective cohort study

Jennifer Welsh, Rosemary J Korda, Grace Joshy, Peter Butterworth, Alex Brown, Emily Banks

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH | BMJ PUBLISHING GROUP | Published : 2017

Abstract

BACKGROUND: Ischaemic heart disease (IHD) incidence is elevated in people reporting psychological distress. The extent to which this relationship is causal or related to reverse causality-that is, undiagnosed disease causing distress-is unclear. We quantified the relationship between psychological distress and IHD, with consideration of confounding and undiagnosed disease. METHODS: Questionnaire data (2006-2009) from 151 811 cardiovascular disease-free and cancer-free Australian general population members aged ≥45years (45 and Up Study) were linked to hospitalisation and mortality data, to December 2013. A two-stage approach estimated HRs for incident IHD (IHD-related hospitalisation or deat..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Health and Medical Research Council


Awarded by Australian Research Council


Funding Acknowledgements

The research was funded by a National Health and Medical Research Council of Australia Partnership Grant (GNT1092674). JW is supported by an Australian Government Research Training Program Scholarship. EB is supported by the National Health and Medical Research Council (1042717). PB is supported by the Australian Research Council Future Fellowship FT13101444. AB is supported by a Veirtel Senior Medical Research Fellowship.