Journal article
Age of red cells for transfusion and outcomes in critically ill adults
DJ Cooper, ZK McQuilten, A Nichol, B Ady, C Aubron, M Bailey, R Bellomo, D Gantner, DO Irving, KM Kaukonen, C McArthur, L Murray, V Pettila, C French
New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 2017
Abstract
BACKGROUND: It is uncertain whether the duration of red-cell storage affects mortality after transfusion among critically ill adults. METHODS: In an international, multicenter, randomized, double-blind trial, we assigned critically ill adults to receive either the freshest available, compatible, allogeneic red cells (short-term storage group) or standard-issue (oldest available), compatible, allogeneic red cells (long-term storage group). The primary outcome was 90-day mortality. RESULTS: From November 2012 through December 2016, at 59 centers in five countries, 4994 patients underwent randomization and 4919 (98.5%) were included in the primary analysis. Among the 2457 patients in the short-..
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Awarded by Helsingin Yliopisto
Funding Acknowledgements
Supported by grants from the Australian National Health and Medical Research Council (NHMRC) (APP102064 and APP1040971), the Health Research Council of New Zealand (12/575), and the Irish Health Research Board (HRA-DI-2014-589 and CTN-2014-012) and by funding from the Australian Red Cross Blood Service. Federal and state governments of Australia fund the Australian Red Cross Blood Service for the provision of blood, blood products, and services to the Australian community. The Medical Research Institute of New Zealand is supported by independent-research-organization funding from the Health Research Council of New Zealand. Drs. Cooper and Bellomo are NHMRC Practitioner Fellows (APPS436629/1041922 and APPS469001/1044787, respectively); Dr. McQuilten is an NHMRC Early Career Fellow (APP1111485). Dr. Cooper reports receiving consulting fees, paid to Monash University, from Eustralis Pharmaceuticals. No other potential conflict of interest relevant to this article was reported.