Conference Proceedings
Molecular basis of esterase-mediated OP resistance in two higher diptera
JG Oakeshott, C Claudianos, PM Campbell, GC Robin, RD Newcomb, WA Odgers, RL Harcourt, RJ Russell, BP Doctor (ed.), P Taylor (ed.), DM Quinn (ed.), RL Rotundo (ed.), MK Gentry (ed.)
STRUCTURE AND FUNCTION OF CHOLINESTERASES AND RELATED PROTEINS | PLENUM PRESS DIV PLENUM PUBLISHING CORP | Published : 1998
Abstract
This paper presents some observations bearing on the interactions of cholinesterases with organophosphates (OPs) that we have gained by analysing some related carboxylesterases. The two groups of proteins lie in the same carboxyl/cholinesterase multigene family and they show at least 25% amino acid sequence identities (1). At the level of tertiary structures the data available for one carboxylesterase (a fungal lipase) show that the a carbons of about 400 of its 540 residues overlap the structure of Torpedo californica AChE (TcAChE) with an r. m. s. deviation of 1.9 angstroms (2). We present the biochemistry and molecular biology of naturally occurring mutations in a particular group of inse..
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