Acceptability and feasibility of a screen-and-treat programme for hepatitis B virus infection in The Gambia: the Prevention of Liver Fibrosis and Cancer in Africa (PROLIFICA) study
Maud Lemoine, Yusuke Shimakawa, Ramou Njie, Makie Taal, Gibril Ndow, Isabelle Chemin, Sumantra Ghosh, Harr F Njai, Adam Jeng, Amina Sow, Coumba Toure-Kane, Souleymane Mboup, Penda Suso, Saydiba Tamba, Abdullah Jatta, Louise Sarr, Aboubacar Kambi, William Stanger, Shevanthi Nayagam, Jessica Howell Show all
The Lancet Global Health | ELSEVIER SCI LTD | Published : 2016
BACKGROUND: Despite the introduction of immunisation for hepatitis B virus (HBV) in the 1990s, HBV-related morbidity and mortality remain high in sub-Saharan Africa. Identification and treatment of asymptomatic people with chronic HBV infection should reduce the disease burden. We therefore assessed the feasibility of a screen-and-treat programme for HBV infection in The Gambia, west Africa, and estimated the proportion of HBV-infected people who had significant liver disease in need of treatment. METHODS: Between Dec 7, 2011, and Jan 24, 2014, individuals living in randomly selected communities in western Gambia were offered hepatitis B surface antigen (HBsAg) screening via a point-of-care ..View full abstract
Awarded by Medical Research Council
European Commission (FP7).