Journal article

BETA-SUBUNIT OF BABOON CHORIONIC-GONADOTROPIN - CONTINUOUS-FLOW FMOC-POLYAMIDE SYNTHESIS OF THE C-TERMINAL 37-PEPTIDE

CR WU, JD WADE, GW TREGEAR

INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH | MUNKSGAARD INT PUBL LTD | Published : 1988

Abstract

The synthesis of a 37-peptide fragment derived from the carboxyl terminal of the beta-subunit of baboon chorionic gonadotropin has been accomplished by the continuous flow Fmoc-polyamide solid phase method. The use of N alpha-fluorenylmethoxy-carbonyl-glutamine with its sidechain protected by the 4,4'-dimethoxybenzhydryl group enabled successful incorporation of this residue onto a hydroxymethyl linkage agent without apparent side reaction.