Journal article

2 DISTINCT SERUM MANNOSE-BINDING LECTINS FUNCTION AS BETA-INHIBITORS OF INFLUENZA-VIRUS - IDENTIFICATION OF BOVINE SERUM BETA-INHIBITOR AS CONGLUTININ

CA HARTLEY, DC JACKSON, EM ANDERS

JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 1992

Abstract

Normal bovine and mouse sera contain a component, termed beta inhibitor, that inhibits the infectivity and hemagglutinating activity of influenza A viruses of the H1 and H3 subtypes. We have previously shown these beta inhibitors to be mannose-binding lectins that apparently act by binding to carbohydrate on the viral hemagglutinin, blocking access of the receptor-binding site to receptors on host cells (E. M. Anders, C. A. Hartley, and D. C. Jackson, Proc. Natl. Acad. Sci. USA 87:4485-4489, 1990). For the H3-subtype virus A/Memphis/1/71 x A/Bel/42 (H3N1), sensitivity to beta inhibitors is determined by the oligosaccharide at residue 165 of the hemagglutinin, this glycosylation site being lo..

View full abstract