Journal article

Mycobacterium avium complex causing endobronchial disease in AIDS patients after partial immune restoration

PB Bartley, AM Allworth, DP Eisen

The International Journal of Tuberculosis and Lung Disease | INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) | Published : 1999


OBJECTIVE: To report the development of an unusual manifestation of pulmonary Mycobacterium avium complex (MAC) infection in two patients with the acquired immune-deficiency syndrome (AIDS) after the commencement of combination antiretroviral chemotherapy. PATIENTS: Two Caucasian males with human immunodeficiency virus (HIV) infection and CD4 lymphocyte counts 100,000 copies/ml who were commenced on combination antiretroviral chemotherapy including a protease inhibitor. RESULTS: Both patients developed endobronchial polypoid tumours within two months of commencing antiretroviral chemotherapy. Histology demonstrated granuloma formation and acid-fast bacilli. Tissue from both patients grew M. ..

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