Journal article

Mild cognitive impairment is associated with subclinical diastolic dysfunction in patients with chronic heart disease

Julian W Sacre, Jocasta Ball, Chiew Wong, Yih-Kai Chan, Simon Stewart, Bronwyn A Kingwell, Melinda J Carrington

EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING | OXFORD UNIV PRESS | Published : 2018

Abstract

Background: To examine mild cognitive impairment and its associations with subclinical cardiac dysfunction in patients with chronic heart disease yet to develop the clinical syndrome of chronic heart failure (CHF). Methods and results: Patients from the Nurse-led Intervention for Less Chronic Heart Failure Study (n = 373 with chronic heart disease other than CHF; 64 ± 11 years, 69% men) were screened for mild cognitive impairment [Montreal cognitive assessment (MoCA) score <26] and underwent echocardiographic/clinical profiling. We investigated associations of mild cognitive impairment and MoCA cognitive domain subscores with global cardiac status ('normal' vs. 'diastolic dysfunction' vs. 'o..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by National Heart Foundation of Australia


Funding Acknowledgements

The NIL-CHF study was supported by a National Health and Medical Research Council (NHMRC) Project Grant (#472662). The study was also supported in part by the Victorian Government's Operational Infrastructure Support Program. J.S., J.B., S.S., and B.A.K. are all supported by NHMRC Fellowships. M.J.C. is supported by a Future Leader Fellowship (#100802) from the National Heart Foundation of Australia and previously throughout the NIL-CHF project, NHMRC Fellowships.