High-LET Radiation Increases Tumor Progression in a K-Ras-Driven Model of Lung Adenocarcinoma
Marie-Liesse Asselin-Labat, Rishi Rampersad, Xia Xu, Matthew E Ritchie, Jacob Michalski, Lingling Huang, Mark W Onaitis
Radiation Research | RADIATION RESEARCH SOC | Published : 2017
High-linear energy transfer (LET) radiation encountered by astronauts in space generates clustered DNA damage that is potentially oncogenic. Analysis of the impact of exposure to space radiation on cancer formation is necessary to determine the best ways to prepare astronauts for space travel so they are protected for the duration of the space mission. A mouse model of lung adenocarcinoma driven by oncogenic K-Ras was used to ascertain the effect of low- and high-LET radiation on tumor formation. We observed increased tumor progression and tumor cell proliferation after single dose or fractionated high-LET doses, which was not observed in mice exposed to low-LET radiation. Location of the tu..View full abstract
Awarded by National Aeronautics and Space Administration (NASA)
This work was funded by the National Aeronautics and Space Administration (NASA grant no. NSCOR NNX11AC60G).