Journal article

Androgen Action via the Androgen Receptor in Neurons Within the Brain Positively Regulates Muscle Mass in Male Mice

Rachel A Davey, Michele V Clarke, Patricia K Russell, Kesha Rana, Jane Seto, Kelly N Roeszler, Jackie MY How, Ling Yeong Chia, Kathryn North, Jeffrey D Zajac

Endocrinology | OXFORD UNIV PRESS INC | Published : 2017

Abstract

Although it is well established that exogenous androgens have anabolic effects on skeletal muscle mass in humans and mice, data from muscle-specific androgen receptor (AR) knockout (ARKO) mice indicate that myocytic expression of the AR is dispensable for hind-limb muscle mass accrual in males. To identify possible indirect actions of androgens via the AR in neurons to regulate muscle, we generated neuron-ARKO mice in which the dominant DNA binding-dependent actions of the AR are deleted in neurons of the cortex, forebrain, hypothalamus, and olfactory bulb. Serum testosterone and luteinizing hormone levels were elevated twofold in neuron-ARKO males compared with wild-type littermates due to ..

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