Androgen Action via the Androgen Receptor in Neurons Within the Brain Positively Regulates Muscle Mass in Male Mice
Rachel A Davey, Michele V Clarke, Patricia K Russell, Kesha Rana, Jane Seto, Kelly N Roeszler, Jackie MY How, Ling Yeong Chia, Kathryn North, Jeffrey D Zajac
Endocrinology | OXFORD UNIV PRESS INC | Published : 2017
Although it is well established that exogenous androgens have anabolic effects on skeletal muscle mass in humans and mice, data from muscle-specific androgen receptor (AR) knockout (ARKO) mice indicate that myocytic expression of the AR is dispensable for hind-limb muscle mass accrual in males. To identify possible indirect actions of androgens via the AR in neurons to regulate muscle, we generated neuron-ARKO mice in which the dominant DNA binding-dependent actions of the AR are deleted in neurons of the cortex, forebrain, hypothalamus, and olfactory bulb. Serum testosterone and luteinizing hormone levels were elevated twofold in neuron-ARKO males compared with wild-type littermates due to ..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by the Sir Edward Dunlop Medical Research Foundation (K.R.), the Austin Medical Research Foundation (R.A.D.), and a Les and Eva Erdi Research Grant (J.D.Z.). R.A.D. was supported by the National Health and Medical Research Council of Australia Project Grant APP1058189.