Journal article

The tubulin repertoire of Caenorhabditis elegans sensory neurons and its context-dependent role in process outgrowth

D Lockhead, EM Schwarz, R O'hagan, S Bellotti, M Krieg, MM Barr, AR Dunn, PW Sternberg, MB Goodman

Molecular Biology of the Cell | Published : 2016

Abstract

Microtubules contribute to many cellular processes, including transport, signaling, and chromosome separation during cell division. They comprise αβ‑tubulin heterodimers arranged into linear protofilaments and assembled into tubes. Eukaryotes express multiple tubulin isoforms, and there has been a longstanding debate as to whether the isoforms are redundant or perform specialized roles as part of a tubulin code. Here we use the well‑characterized touch receptor neurons (TRNs) of Caenorhabditis elegans to investigate this question through genetic dissection of process outgrowth both in vivo and in vitro. With single‑cell RNA-seq, we compare transcription profiles for TRNs with those of two ot..

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University of Melbourne Researchers

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