Widespread Volumetric Reductions in Schizophrenia and Schizoaffective Patients Displaying Compromised Cognitive Abilities

TE Van Rheenen; V Cropley; A Zalesky; C Bousman; R Wells; J Bruggemann; S Sundram; D Weinberg; RK Lenroot; A Pereira; C Shannon Weickert; TW Weickert; C Pantelis

Journal article

Widespread Volumetric Reductions in Schizophrenia and Schizoaffective Patients Displaying Compromised Cognitive Abilities

TE Van Rheenen, V Cropley, A Zalesky, C Bousman, R Wells, J Bruggemann, S Sundram, D Weinberg, RK Lenroot, A Pereira, C Shannon Weickert, TW Weickert, C Pantelis

Schizophrenia Bulletin | OXFORD UNIV PRESS | Published : 2018

DOI: 10.1093/schbul/sbx109

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Abstract

Objective: Progress toward understanding brain mechanisms in psychosis is hampered by failures to account for within-group heterogeneity that exists across neuropsychological domains. We recently identified distinct cognitive subgroups that might assist in identifying more biologically meaningful subtypes of psychosis. In the present study, we examined whether underlying structural brain abnormalities differentiate these cognitively derived subgroups. Method: 1.5T T1 weighted structural scans were acquired for 168 healthy controls and 220 patients with schizophrenia/ schizoaffective disorder. Based on previous work, 47 patients were categorized as being cognitively compromised (impaired prem..

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University of Melbourne Researchers

Tamsyn van Rheenen Author

Vanessa Cropley Author

Andrew Zalesky Author

Christos Pantelis Author

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Grants

Awarded by Brain and Behavior Research Foundation

Funding Acknowledgements

Dr Van Rheenen was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship (APP1088785). Dr Cropley was supported by an NHMRC Early Career Fellowship (628880), a Brain and Behavior Research Foundation (NARSAD) Young Investigator Award (21660), and a University of Melbourne Faculty of Medicine, Dentistry, and Health Sciences Research Fellowship. Dr Zalesky was supported by an NHMRC Fellowship (1047648). Dr Bousman was supported by a University of Melbourne Research Fellowship and a NARSAD Young Investigator Award (20526). Dr Pereira was supported by the One-in-Five Association and the AMP Foundation. Prof Shannon Weickert was supported by an NHMRC Principal Research Fellowship (1117079), the NSW Ministry of Health, Office of Health and Medical Research, the University of New South Wales, and Neuroscience Research Australia. Dr Pantelis was supported by an NHMRC Senior Principal Research Fellowship (628386 and 1105825) and by a NARSAD Distinguished Investigator Award.