Effects of locally generated angiotensin II on noradrenergic transmission in guinea-pig isolated atria.
J Ziogas, DF Story, MJ Rand
Eur J Pharmacol | Published : 1984
The extent to which cardiac neuroeffector function may be modulated by angiotensin II (AII) generated locally from angiotensin I (AI) was investigated in guinea-pig spontaneously beating isolated atria radiolabelled with [3H]noradrenaline. AI and AII were equipotent in increasing the rate and force of atrial contractions with a threshold concentration between 0.1 and 1.0 nM. In contrast, AI was approximately twenty times less potent than AII in enhancing the stimulation-induced (S-I) efflux of radioactivity. The actions of AI and AII on rate and force of atrial contractions, as well as those on S-I efflux of radioactivity, were substantially blocked by the AII receptor antagonist saralasin. ..View full abstract