An electrophysiological study of the actions of angiotensin II at the sympathetic neuroeffector junction in the guinea‐pig vas deferens

Abstract

The effects of angiotensin II on sympathetic neuroeffector transmission in the guinea‐pig vas deferens have been investigated by the use of intracellular and focal extracellular recording techniques to measure indirectly, the release of adenosine 5′‐triphosphate (ATP). Angiotensin II (10–100 nm) did not alter the amplitude of the first excitatory junction potential (e.j.p.) in a train but increased the amplitude of subsequent e.j.ps. There was a corresponding increase in the probability of occurrence of extracellularly recorded evoked excitatory junction currents (e.j.cs). Spontaneous quantal transmitter release was unaffected by angiotensin II. The enhancement of transmitter release produce..