Journal article

Inherent variability of pulmonary function tests in infants with bronchiolitis.

J Mallol, ME Hibbert, CF Robertson, A Olinsky, PD Phelan, PD Sly

Pediatr Pulmonol | Published : 1988

Abstract

During the last decade, many new methods of assessing pulmonary function in infants have been introduced. However, considerable controversy has arisen when these different techniques are used to assess the efficacy of various inhaled medications. The currently employed measures of pulmonary function have been reported to have coefficients of variation of less than 10%. However, these figures refer to repeated measurements made in individual babies over a short period of time, with the infant in a constant position. They may not be applicable to studies on the effects of drugs when a significant time interval elapses between measurements, particularly if the infant is repositioned during this..

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