Identification, localization, and regulation of insulin-like growth factor binding proteins and their messenger ribonucleic acids in the newborn rat olfactory bulb.
VC Russo, SR Edmondson, FA Mercuri, CR Buchanan, GA Werther
Endocrinology | Published : 1994
Insulin-like growth factor binding proteins (IGFBPs) have been identified in most tissues, including the central nervous system, where the major IGFBPs have been localized. The regulation and roles of IGFBPs in IGF action in the developing brain remain unclear. In this study we examined the expression and anatomical distribution of IGFBP messenger RNAs (mRNAs) in the newborn rat olfactory bulb (OB) during the first postnatal week. We used our recently developed newborn rat OB organ culture system, which emulates the first week of in vivo development, to identify and characterize expressed and secreted IGFBPs and to determine the role of the local growth factors IGF-I and basic fibroblast gro..View full abstract