Journal article

Cytokeratin 8, 18 and 19 expressions, epithelial shedding, and stromal extravasation in endometrium of norethisterone enanthate (NET-EN) progestogen contraceptive users: (A preliminary report)

S Wonodirekso, W Hadisaputra, B Affandi, B Siregar, PAW Rogers

Medical Journal of Indonesia | Published : 1998


Cytokeratins 8, 18 and 19 are members of the cytoskeletal intermediate filament (IF) family found in all simple epithelia. Intermediate filaments are dynamic intracytoplasmic structures that can be influenced by a number of external factors. Norethisterone-enanthate (NET-EN) is a long-acting progestogen contraceptive that has been found to arrest endometrial growth in the rat. Progestogen contraceptives including levonorgestrel (LNG, Norplant®) implant, injectable depot-medroxyprogesterone acetate (DMPA) and norethisterone-enanthate (NET-EN) are known to cause bleeding problems among users that are responsible for more than 50% of the withdrawals from these methods. The aim of this study was..

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