Endometrial biopsy collection from women receiving Norplant®

Abstract

This paper reports a series of 191 endometrial biopsy procedures performed on Indonesian women who had received between 3 and 12 months exposure to Norplant®. 87 biopsy procedures were attempted with a microhysteroscope using biopsy forceps, and 104 procedures were attempted with either Pi pelle or Karman suction curettes. Regardless of biopsy method, diagnosable endometrium was only obtained in approximately 50% of procedures. Myometrium was often found in microhysteroscope but not suction biopsies. Analysis of a number of clinical characteristics showed that women from whom diagnosable endometrial tissue was obtained had higher mean peripheral oestrogen levels in the 2 weeks prior to biops..