Endometrial endothelial cell proliferation during the menstrual cycle

Abstract

Adult endometrium is a tissue in which physiological angiogenesis occurs regularly and provides an accessible source of material for study. Endometrial biopsies and immunohistochemistry were used to test two hypotheses: firstly, that there are peaks of endothelial cell proliferation in human endometrium during the menstrual cycle, and secondly that in-vitro endothelial cell migratory signal production by human endometrium (measured in a previous study) accompanies endothelial cell proliferative activity in vivo. Proliferating cells were identified using anti-proliferating cell nuclear antigen, and endothelial cells were identified using anti-CD34. The method was validated by a smaller, separ..