Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas.

Shokoufeh Shahrabi-Farahani; Lili Wang; Bernadette MM Zwaans; Jeans M Santana; Akio Shimizu; Seiji Takashima; Michael Kreuter; Leigh Coultas; Patricia A D'Amore; Jeffrey M Arbeit; Lars A Akslen; Diane R Bielenberg

Journal article

Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas.

Shokoufeh Shahrabi-Farahani, Lili Wang, Bernadette MM Zwaans, Jeans M Santana, Akio Shimizu, Seiji Takashima, Michael Kreuter, Leigh Coultas, Patricia A D'Amore, Jeffrey M Arbeit, Lars A Akslen, Diane R Bielenberg

Lab Invest | Published : 2014

DOI: 10.1038/labinvest.2014.66

Abstract

Neuropilins (NRPs) are cell surface receptors for vascular endothelial growth factor (VEGF) and SEMA3 (class 3 semaphorin) family members. The role of NRPs in neurons and endothelial cells has been investigated, but the expression and role of NRPs in epithelial cells is much less clear. Herein, the expression and localization of NRP1 was investigated in human and mouse skin and squamous cell carcinomas (SCCs). Results indicated that NRP1 mRNA and protein was expressed in the suprabasal epithelial layers of the skin sections. NRP1 staining did not overlap with that of keratin 14 (K14) or proliferating cell nuclear antigen, but did co-localize with staining for keratin 1, indicating that diffe..

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