Journal article

The cytoplasmic domain of tissue factor in macrophages augments cutaneous delayed-type hypersensitivity

Jim Apostolopoulos, Michael J Hickey, Laveena Sharma, Piers Davenport, Leon Moussa, Will G James, Julia L Gregory, A Richard Kitching, Ming Li, Peter G Tipping

Journal of Leukocyte Biology | FEDERATION AMER SOC EXP BIOL | Published : 2008

Abstract

In addition to its procoagulant role, tissue factor (TF) has important coagulation-independent roles, including in inflammation. The cytoplasmic domain of TF has been implicated in some of these coagulation-independent roles, particularly cell signaling. To assess the contribution of the cytoplasmic domain of TF to cell-mediated adaptive immunity, the development of cutaneous delayed-type hypersensitivity (DTH) was studied in mice lacking the cytoplasmic domain of TF (TF(deltaCT/deltaCT) mice). DTH responses in sensitized mice were significantly attenuated in TF(deltaCT/deltaCT) mice, and leukocyte-endothelial cell interactions, assessed by intravital microscopy, were impaired significantly...

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University of Melbourne Researchers