Fluctuations of plasma phenytoin levels on single dose and twice daily dose regimes.
FJ Vajda, J Merory, PF Bladin
Clinical and Experimental Neurology | Published : 1975
Eight chronic refractory epileptics were studied with regard to frequency of administration of phenytoin. There were no excessive fluctuations in plasma levels when the total drug dose was given as a single daily dose, and the clinical state of the patients was unchanged from that on twice daily dosage.