TGF-beta and IL-6 family signalling crosstalk: an integrated model
Shabnam Khatibi, Jeff Babon, John Wagner, Jonathan H Manton, Chin Wee Tan, Hong-Jian Zhu, Sam Wormald, Antony W Burgess
GROWTH FACTORS | TAYLOR & FRANCIS LTD | Published : 2017
Mathematical models for TGF-β and IL-6 signalling have been linked, providing a platform for analyzing the crosstalk between the systems. An integrated IL-6:TGF-β model was developed via a reduced set of reaction equations which incorporate both feedback loops and appropriate time-delays for transcription and translation processes. The model simulates stable, robust and realistic responses to both ligands. Pulsatile (multiple pulses) inputs for both TGF-β and IL-6 have been simulated to investigate the effects of each ligand on the sensitivity, equilibrium and dynamic responses of the integrated signalling system. In our simulations the crosstalk between constant IL-6 and TGF-β signalling vi..View full abstract
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Awarded by NHMRC
S. K. was supported by Melbourne International Research Scholarship and Melbourne International Fee Remission Scholarship from the University of Melbourne. A. W. B. was supported by the Ludwig Institute for Cancer Research and NHMRC Program Grant no. 487922.