Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction
Tobias L Haas, Christoph H Emmerich, Bjoern Gerlach, Anna C Schmukle, Stefanie M Cordier, Eva Rieser, Rebecca Feltham, James Vince, Uwe Warnken, Till Wenger, Ronald Koschny, David Komander, John Silke, Henning Walczak
Molecular Cell | CELL PRESS | Published : 2009
Awarded by NHMRC
Awarded by Cancer Research UK
Awarded by Medical Research Council
We thank M.R. Sprick, M. Leverkus, P.H. Krammer, Y. Kulathu, and all members of the Walczak Lab for helpful discussions; D. Brenner, R. Arnold, and M. Li Weber for the gift of plasmids; S. Wandschneider and M. Schnolzer for MS analysis early in the project; M. Pasparakis for NEMO- and TRADD-deficient MEFs; H. Nakano for TRAF2/5 double knockout MEFs; M. Kelliher for the gift of RIP1 knockout mice; P. Seneci and L. Manzoni for the IAP inhibitor SM-164 (SMAC059); and C. Rappi for technical assistance. H.W. is founder, shareholder, and scientific advisor of Apogenix GmbH. J.S. is a consultant to TetraLogic Pharmaceuticals and funded by the NHMRC (433013, 541901, and 541902). T.L.H., E.R., and H.W. are funded by the EU Marie Curie Research Training Network "ApopTrain."