Journal article

Age-related changes in the kinetics of water transport in normal human lenses

BA Moffat, KA Landman, RJW Truscott, MHJ Sweeney, JM Pope

EXPERIMENTAL EYE RESEARCH | ACADEMIC PRESS LTD | Published : 1999

Abstract

Magnetic resonance microscopy (MRM) has been used to study the kinetics of water transport in human eye lenses. Fresh lenses obtained from the Queensland Eye Bank were incubated at 34.5 degrees C in artificial aqueous humour (AAH) containing nutrients and metabolites similar to those that are present in vivo. MR images were acquired over approximately a 20 hr period following replacement of H(2)O based AAH with deuterium oxide (D(2)O) based AAH. NMR signal intensity from the lenses decreased with time corresponding to a decrease in concentration of H(2)O within the lenses. A statistically significant correlation (P<0.001) was found between the rate of NMR signal loss from the lens nuclei and..

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University of Melbourne Researchers