PARTIAL STRUCTURE OF THE GENE ENCODING THE 78 KDA GASTRIN BINDING-PROTEIN EXCLUDES A CLOSE RELATIONSHIP WITH THE PEROXISOMAL TRIFUNCTIONAL ENZYME
GS BALDWIN, A CASEY, J WEINSTOCK
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | Published : 1993
A 10.9 kb porcine genomic clone encoding nucleotides 124-732 of the cDNA for the porcine 78 kDa gastrin-binding protein has been isolated and characterized. The coding sequence is interrupted by 7 introns, which vary in length from 93 to 3000bp. The positions of the intron/exon junctions are different from the junctions in the gene encoding the rat peroxisomal trifunctional enzyme. Despite 33% amino acid sequence identity between the two proteins it is concluded that the porcine gastrin binding protein is not closely related to the rat trifunctional enzyme.