Journal article
Declining Malaria Transmission Differentially Impacts the Maintenance of Humoral Immunity to Plasmodium falciparum in Children
CK Mugyenyi, SR Elliott, XZ Yap, G Feng, P Boeuf, G Fegan, FFH Osier, FJI Fowkes, M Avril, TN Williams, K Marsh, JG Beeson
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2017
Abstract
Background We investigated the poorly understood impact of declining malaria transmission on maintenance of antibodies to Plasmodium falciparum merozoite antigens and infected erythrocytes (IEs), including functional immunity. Methods In a 3-year longitudinal cohort of 300 Kenyan children, antibodies to different AMA1 and MSP2 alleles of merozoites, IE surface antigens, and antibody functional activities were quantified. Results Over a period in which malaria transmission declined markedly, AMA1 and MSP2 antibodies decreased substantially; estimated half-lives of antibody duration were 0.8 year and 1-3 years, respectively. However, 69%-74% of children maintained their seropositivity to AMA1 ..
View full abstractGrants
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (program grant to J.G.B.; senior research fellowship to J.G.B.; and Infrastructure for Research Institutes Support Scheme Grant); Australia Research Council (Future Fellowship to F. J. I. F.); Wellcome Trust; and the Victorian State Government Operational Infrastructure Support.