Workshop summary: Novel aspects of the functions of the TRAFs and cIAPs

Abstract

Session 8 of TNF2009 focused on the function of the RING containing proteins TRAF2 and cIAPs in TNF signaling. TNF-R1 signaling is understood to be carefully balanced between a pro-survival and pro-apoptotic response and, as might be expected for proteins containing these E3 ligase domains, much of the data and discussion revolved around the regulation of these alternative pathways by ubiquitylation. The session was also notable for talks that extended dramatically our understanding of regulation of other signaling pathways by cIAPs such as necrosis and immune responses. Furthermore there was thought provoking data looking at the role of the RIP kinase family in TNF signaling and the role th..