Journal article
In vivo control of B-cell survival and antigen-specific B-cell responses
TD Chan, S Gardam, D Gatto, VM Turner, J Silke, R Brink
Immunological Reviews | WILEY | Published : 2010
Abstract
Targeted modification of the mouse genome provides the capability to manipulate complex physiological processes in a precise and controlled manner. Investigation of B-lymphocyte biology has benefited not only from the targeted modification of genes controlling B-cell survival and responsiveness, but also from the manipulation of antigen specificity made possible by targeting endogenous immunoglobulin loci. In this review, we discuss recent results obtained from our laboratory using gene-targeted mouse models to investigate the in vivo regulation of B-cell survival and responsiveness. The control of BAFF-dependent survival signals by the TRAF2- and TRAF3-signaling proteins is discussed as is ..
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Funding Acknowledgements
Thanks go to the many present and past members of the laboratory who have also contributed to the work described here: Adrian Grech, Marilyn Thien, Tri Phan, Didrik Paus, Tahra Camidge, and Katherine Wood. Thank you also to key collaborators Stuart Tangye, Fabienne Mackay, Charles Mackay, Carola Vinuesa, and Chris Goodnow. Special thanks goes to Prof. Antony Basten for his invaluable encouragement and support over many years. The work described here was supported primarily by the National Health and Medical Research Council of Australia with additional support from Cancer Institute New South Wales and the Alliance for Lupus Research.