Journal article
IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis
M Gyrd-Hansen, M Darding, M Miasari, MM Santoro, L Zender, W Xue, T Tenev, PCA da Fonseca, M Zvelebil, JM Bujnicki, S Lowe, J Silke, P Meier
Nature Cell Biology | NATURE PUBLISHING GROUP | Published : 2008
DOI: 10.1038/ncb1789
Abstract
The covalent attachment of ubiquitin to target proteins influences various cellular processes, including DNA repair, NF-κB signalling and cell survival. The most common mode of regulation by ubiquitin-conjugation involves specialized ubiquitin-binding proteins that bind to ubiquitylated proteins and link them to downstream biochemical processes. Unravelling how the ubiquitin-message is recognized is essential because aberrant ubiquitin-mediated signalling contributes to tumour formation. Recent evidence indicates that inhibitor of apoptosis (IAP) proteins are frequently overexpressed in cancer and their expression level is implicated in contributing to tumorigenesis, chemoresistance, disease..
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Awarded by National Cancer Institute
Funding Acknowledgements
We would like to thank Xiaolu Yang, David Komander, David Barford, Thomas Farkas, Ivan Dikic and Marja Jaattela for reagents, discussions and invaluable technical support. We thank Irene Scarf for help with the cIAP1 zebrafish experiments, and Hyejin Cho and Beicong Ma for excellent technical assistance and help with the mouse tumour model. We thank Alan Ashworth and members of the Meier laboratory for critical reading of the manuscript and helpful discussions. We thank Vishva Dixit for sharing unpublished results. M. G.- H. is supported by a fellowship from the Danish Cancer Society. M. M. S. is supported by a HFSP Career Developmental Award, Fondazione San Paolo and Regione Piemonte.