IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappa B as well as cell survival and oncogenesis
Mads Gyrd-Hansen, Maurice Darding, Maria Miasari, Massimo M Santoro, Lars Zender, Wen Xue, Tencho Tenev, Paula CA da Fonseca, Marketa Zvelebil, Janusz M Bujnicki, Scott Lowe, John Silke, Pascal Meier
Nature Cell Biology | NATURE PUBLISHING GROUP | Published : 2008
We would like to thank Xiaolu Yang, David Komander, David Barford, Thomas Farkas, Ivan Dikic and Marja Jaattela for reagents, discussions and invaluable technical support. We thank Irene Scarf for help with the cIAP1 zebrafish experiments, and Hyejin Cho and Beicong Ma for excellent technical assistance and help with the mouse tumour model. We thank Alan Ashworth and members of the Meier laboratory for critical reading of the manuscript and helpful discussions. We thank Vishva Dixit for sharing unpublished results. M. G.- H. is supported by a fellowship from the Danish Cancer Society. M. M. S. is supported by a HFSP Career Developmental Award, Fondazione San Paolo and Regione Piemonte.