Journal article
Age-related susceptibility to severe malaria associated with galectin-2 in Highland Papuans
LM Randall, E Kenangalem, DA Lampah, E Tjitra, ED Mwaikambo, T Handojo, KA Piera, ZZ Zhao, F De Labastida Rivera, Y Zhou, KM McSweeney, L Le, FH Amante, A Haque, AC Stanley, T Woodberry, E Salwati, DL Granger, MR Hobbs, RN Price Show all
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2010
DOI: 10.1086/653125
Abstract
Background. Age and host genetics are important determinants of malaria severity. Lymphotoxin-α (LTα) has been associated with the development of cerebral malaria (CM) and other severe malaria (SM) syndromes. Mutations in genes regulating LTa production contribute to other acute vascular diseases and may contribute to malaria pathogenesis. Methods. We tested the association between rs7291467, a single-nucleotide polymorphism (SNP) in the LTαrelated gene encoding galectin-2 (LGALS2), disease severity, and function in a case-control study of ethnic Highland Papuan adults and children with SM (n = 380) and asymptomatic malaria-exposed controls (n = 356) originating from a non-malaria-endemic re..
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Awarded by National Institutes of Health
Funding Acknowledgements
Financial support: National Institutes of Health (grants AI55982 and AI041764); the Australian National Health and Medical Research Council (program grants 290208 and 496600 and fellowships to C. R. E., N.M.A. and G. M.); the US Veterans Affairs Research Service; Australian Postgraduate Award (to L. M. R.); Wellcome Trust Career Development Award (to R.N.P.); the Tudor Foundation.