Journal article

Analysis of Behavior and Trafficking of Dendritic Cells within the Brain during Toxoplasmic Encephalitis

Beena John, Brendon Ricart, Elia D Tait Wojno, Tajie H Harris, Louise M Randall, David A Christian, Beth Gregg, Daniel Manzoni De Almeida, Wolfgang Weninger, Daniel A Hammer, Christopher A Hunter

PLOS PATHOGENS | PUBLIC LIBRARY SCIENCE | Published : 2011

Abstract

Under normal conditions the immune system has limited access to the brain; however, during toxoplasmic encephalitis (TE), large numbers of T cells and APCs accumulate within this site. A combination of real time imaging, transgenic reporter mice, and recombinant parasites allowed a comprehensive analysis of CD11c+ cells during TE. These studies reveal that the CNS CD11c+ cells consist of a mixture of microglia and dendritic cells (DCs) with distinct behavior associated with their ability to interact with parasites or effector T cells. The CNS DCs upregulated several chemokine receptors during TE, but none of these individual receptors tested was required for migration of DCs into the brain. ..

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University of Melbourne Researchers

Grants

Awarded by State of Pennsylvania


Awarded by NHMRC


Awarded by OSMR NSW


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This work was supported by grants to CAH, WW, DAH and BR (BJ: R21 AI090234 CAH: T32 AI07532, RO1 AI071302, State of Pennsylvania, WW: NHMRC grant 512265 and a grant from the OSMR NSW, DAH: RO1 AI082292, BR: Merck & Co. Fellowship). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.