Journal article

A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults

Louise M Randall, Enny Kenangalem, Daniel A Lampah, Emiliana Tjitra, Esther D Mwaikambo, Tjandra Handojo, Kim A Piera, Zhen Z Zhao, Fabian de Labastida Rivera, Yonghong Zhou, Karli M McSweeney, Lien Le, Fiona H Amante, Ashraful Haque, Amanda C Stanley, Tonia Woodberry, Ervi Salwati, Donald L Granger, Maurine R Hobbs, Ric N Price Show all

MALARIA JOURNAL | BMC | Published : 2010

Abstract

BACKGROUND: Severe malaria (SM) syndromes caused by Plasmodium falciparum infection result in major morbidity and mortality each year. However, only a fraction of P. falciparum infections develop into SM, implicating host genetic factors as important determinants of disease outcome. Previous studies indicate that tumour necrosis factor (TNF) and lymphotoxin alpha (LTα) may be important for the development of cerebral malaria (CM) and other SM syndromes. METHODS: An extensive analysis was conducted of single nucleotide polymorphisms (SNPs) in the TNF, LTA and LTB genes in highland Papuan children and adults, a population historically unexposed to malaria that has migrated to a malaria endemic..

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Grants

Awarded by National Institutes of Health


Awarded by Australian NHMRC


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This work was supported by grants from the National Institutes of Health (AI55982 and AI041764), Australian NHMRC Programme Grants (290208 and 496600), the US V. A. Research Service, Australian Postgraduate Award to LMR, Australian NHMRC Fellowships to CRE, NMA and GM, Wellcome Trust Career Development Award to RNP and the Tudor Foundation.