Journal article

EXOGENOUS CALCITONIN-GENE-RELATED PEPTIDE CAUSES GUBERNACULAR DEVELOPMENT IN NEONATAL (TFM) MICE WITH COMPLETE ANDROGEN RESISTANCE

AL GRIFFITHS, W MIDDLESWORTH, DW GOH, JM HUTSON

JOURNAL OF PEDIATRIC SURGERY | W B SAUNDERS CO-ELSEVIER INC | Published : 1993

Abstract

It has been proposed that testicular descent is controlled indirectly by androgens acting on the central nervous system to mediate migration of the gubernaculum to the scrotum. Accumulating evidence suggests that the genitofemoral nerve may release a newly described neurotransmitter, calcitonin gene-related peptide (CGRP) to stimulate gubernacular motility during migration. This study aimed to determine whether exogenous CGRP could stimulate gubernacular migration in mice with complete androgen resistance (testicular feminization mouse [Tfm]). CGRP was injected into the right groin of neonatal Tfm mice at 2-day intervals until 2 weeks of age, when the length of the processus vaginalis was me..

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