Journal article

BOTH GONADOTROPIN AND TESTOSTERONE FAIL TO REVERSE ESTROGEN-INDUCED CRYPTORCHIDISM IN FETAL MICE - FURTHER EVIDENCE FOR NONANDROGENIC CONTROL OF TESTICULAR DESCENT IN THE FETUS

JM HUTSON, LM WATTS, J MONTALTO, S GRECO

PEDIATRIC SURGERY INTERNATIONAL | SPRINGER VERLAG | Published : 1990

Abstract

Estradiol benzoate (E2B) causes cryptorchidism in fetal mice, with suppression of androgen secretion. Simultaneous gonadotropin (hCG) injection was reported to restore Leydig cell function and testosterone mediates testicular descent. To investigate whether hCG or testosterone fully reverses the cryptorchidism as well as testosterone secretion, fetal mice were exposed to E2B with or without hCG/testosterone. Normal transabdominal testicular descent was significantly inhibited by E2B or diethylstilbestrol injection on day 14 of gestation (n = 41; P < 0.005). Both hCG 50-100 IU (n = 59) and testosterone 5 mg (n = 45) given simultaneously with E2B failed to restore normal testicular descent (P ..

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