Journal article

Validity of markers of dilution in small volume lung lavage

PA Dargaville, M South, P Vervaart, PN McDougall

American Journal of Respiratory and Critical Care Medicine | AMER LUNG ASSOC | Published : 1999


Definitive analysis of solute concentrations in lung lavage fluid involves the use of a marker of dilution to correct for variable recovery of epithelial lining fluid (ELF), but the question of the most appropriate dilutional marker remains unresolved. In lavage fluid collected from infants with lung disease and healthy control subjects, we examined ELF concentration of protein, albumin, sphingomyelin (SM), and IgA secretory component (SC), and critically appraised the relative validity of SC and urea as dilutional markers in the context of lung infection and lung injury. Protein, albumin, and SM were found not to be valid dilutional markers, as their ELF concentration varied significantly b..

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