σ receptors on NCB-20 hybrid neurotumor cells labeled with ( )[3H]SKF 10,047 and ( )[3H]3-PPP

Abstract

(+)[3H]SKF 10,047 and (+)[3H]3-PPP label a homogeneous population of sites in NCB-20 cell membranes that apparently represent benzomorphan specific binding sites previously reported for this cell line. Their drug specificity indicates that these sites are very similar to σ receptor binding sites labeled in brain tissues by these ligands and do not represent PCP receptors. © 1986.