Journal article

LOCALIZATION OF H-3 DIHYDROERGOTAMINE BINDING-SITES IN THE CAT CENTRAL-NERVOUS-SYSTEM - RELEVANCE TO MIGRAINE

PJ GOADSBY, AL GUNDLACH

ANNALS OF NEUROLOGY | LITTLE BROWN CO | Published : 1991

Abstract

Dihydroergotamine (DHE) is the treatment of choice in aborting the acute attack of migraine. Although its efficacy has been known for 40 years, its mechanism of action is still disputed. Data regarding the site of action of dihydroergotamine may provide an insight into its mechanism of action and thus identify a locus of potentially abnormal pathophysiology in migraine. By using in vitro and ex vivo autoradiographic techniques, the localization of specific binding sites for 3H-dihydroergotamine in the cat brain has been examined. Binding was seen in the dorsal horn of the cervical spinal cord, in the medulla, associated with the nucleus of the tractus solitarius, area postrema, and descendin..

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