Journal article
Simultaneous measurement of dothiepin and its major metabolites in plasma and whole blood by gas chromatography-mass fragmentography
KP Maguire, TR Norman, GD Burrows, BA Scoggins
Journal of Chromatography B Biomedical Sciences and Applications | ELSEVIER SCIENCE BV | Published : 1981
Abstract
A method for the simultaneous measurement of dothiepin and two of its major metabolites, northiaden and dothiepin S-oxide in both plasma and whole blood is described. The method involves the use of gas chromatography-mass fragmentography. It is selective, sensitive (1 μg/l) and reproducible. It has been used to analyse both plasma and blood samples following single oral doses of 75 mg dothiepin in seven volunteers. © 1981.