SAFETY OF ZIMELDINE IN OVERDOSE

Abstract

Zimeldine, which has highly selective effects on serotonergic receptors, is an effective treatment for depressive illness. Because of its selective receptor specificity few side effects, especially on the cardiovascular system, have been reported. In one case of overdosage only minor flattening of T waves was observed on the electrocardiogram. Postural hypotension, which may limit the dosage of other anti-depressants, particularly in the elderly is less common with zimeldine. We report a case of zimeldine overdose that confirms the above observation.