Journal article

ZIMELDINE IN DEPRESSIVE-ILLNESS - EFFICACY AND SAFETY DATA

GD BURROWS, TR NORMAN, PF MARRIOTT, B DAVIES

ACTA PSYCHIATRICA SCANDINAVICA | MUNKSGAARD INT PUBL LTD | Published : 1983

Abstract

Two studies of zimeldine in depressive illness are reported, one a double-blind, placebo-controlled trial, the other an open evaluation. In both studies, zimeldine was shown to have antidepressant properties. No simple relationship between plasma zimeldine or norzimeldine and clinical effect was demonstrated in eight patients treated for 6 weeks. Minor changes in electrocardiographic parameters were noted in some zimeldine patients. Side-effects attributable to zimeldine treatment were generally of mild to moderate severity and the drug was well tolerated. During the studies, one patient overdosed on zimeldine (5.2 g) and, although plasma concentrations were excessive, minimum side-effects w..

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