Journal article

LIGAND-BINDING AND PLATELET UPTAKE STUDIES OF LOXAPINE, AMOXAPINE AND THEIR 8-HYDROXYLATED DERIVATIVES

A FULTON, T NORMAN, GD BURROWS

JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER SCIENCE BV | Published : 1982

Abstract

Loxapine, amoxapine and their 8-hydroxylated derivatives were studied by means of [3H]imipramine binding to rat cortical membranes, [3H]spiperone binding to rat striatal membranes, and the inhibition of serotonin uptake by human platelets. As inhibitors of [3H]imipramine binding: amoxapine greater than hydroxyamoxapine greater than loxapine = hydroxyloxapine; as inhibitors of platelet serotonin uptake: hydroxyamoxapine greater than amoxapine greater than hydroxyloxapine greater than loxapine; and as inhibitors of [3H]spiperone binding: loxapine greater than amoxapine greater than hydroxyamoxapine greater than hydroxyloxapine. The antipsychotic properties of loxapine and amoxapine were suppor..

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University of Melbourne Researchers