Journal article
Plasma nomifensine concentration. Cardiological effects and clinical response
IM McIntyre, GD Burrows, TR Norman, P Dumovic, J Vohra
International Pharmacopsychiatry | Published : 1980
DOI: 10.1159/000468458
Abstract
Cardiological effects of nomifensine were studied in 10 endogenously depressed in-patients receiving up to 200 mg/day for 3 weeks. No significant cardiac effects were observed using His' bundle electrography and electrocardiography. 9 of the 10 patients showed a significant recovery from their depressive illness. Plasma nomifensine concentrations at day 22 were not correlated with clinical response, blood pressure, or electrocardiographic parameters. A negative correlation between A-H interval, in the His' bundle electrogram, and day 22 nomifensine concentration was observed.