Journal article
PLATELET MONOAMINE OXIDASE ACTIVITY IN PATIENTS WITH HUNTINGTON'S DISEASE
TR Norman, E Chiu, MA French
Clinical and Experimental Pharmacology and Physiology | BLACKWELL SCIENCE | Published : 1987
Abstract
1. Platelet monoamine oxidase (MAO) activity was investigated in 30 patients with Huntington's disease and compared with the activity in a control group. 2. Significantly elevated activity was found in the patients (P < 0.05; t‐test) when same sex contrasts were carried out to account for the well known influence of sex on MAO activity. 3. The mean MAO activity in male patients was 23.5±6.0 nmol/mg protein per h and female patients was 29.5 ± 8.9 nmol/mg protein per h using tyramine as the substrate. 4. The possible influence of environmental factors on the results is discussed. Copyright © 1987, Wiley Blackwell. All rights reserved